CHN1

Across TCGA patient cohorts, CHN1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHN1-associated genes across cancer lineages are Notch1, ATM, and Chk1. Each is linked with CHN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHN1-to-partner and partner-to-CHN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CHN1-low versus CHN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHN1→partner) and Y-score (partner→CHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.258	+3.013	<.001	.018	3	2
UCEC	ATM →	-0.550	-2.986	.012	.035	3	2
SKCM	Chk1 →	+0.213	+2.204	.032	.033	3	2
UCEC	JNK2 →	+0.277	+2.459	.003	.020	3	1
UCEC	p62 Lck ligand →	+0.354	+3.179	.024	.010	3	1
UCEC	PCNA →	+0.239	+3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by CHN1 expression — UCEC

Explore this box plot interactively →