CHMP4C

Across TCGA patient cohorts, CHMP4C mutation is significantly associated with the RNA expression of many other genes, with 611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP4C-associated genes across cancer lineages are SNX3P1X, CRYBB2P1, and DHRS2. Each is linked with CHMP4C in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP4C-to-partner and partner-to-CHMP4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1X grouped by CHMP4C-low versus CHMP4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4C→partner) and Y-score (partner→CHMP4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX3P1X →	+0.255	+3.356	<.001	.005	3	2
UCEC	CRYBB2P1 →	+0.651	+3.343	.002	.005	3	1
UCEC	DHRS2 →	+1.224	+3.343	.001	.005	3	1
UCEC	NDUFAF5 →	+0.439	+3.397	.004	.004	3	1
UCEC	PXMP4 →	+0.854	+3.354	.006	.005	3	1
UCEC	EARS2 →	+0.750	+3.202	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 611 associations by consensus.

SNX3P1X by CHMP4C expression — UCEC

Explore this box plot interactively →