CHMP4C

Across TCGA pan-cancer cohorts, CHMP4C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CHMP4C data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHMP4C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CHMP4C expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

KIRC, CESC, and PAAD are the cancer types where CHMP4C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.706	0.545	<.001	108	view →
CESC	DFS	Tertile	All	0.391	0.687	.001	108	view →
PAAD	DFS	Tertile	All	0.201	0.536	<.001	65	view →
BLCA	OS	Median	II,III,IV	0.527	0.343	.005	49	view →
LGG	OS	Tertile	All	0.344	0.502	<.001	36	view →
LUSC	DFS	Median	All	0.599	0.721	<.001	35	view →
LAML	DFS	Tertile	All	0.163	0.537	.003	34	view →
SARC	DFS	Median	All	0.687	0.532	.001	29	view →
LUAD	OS	Median	All	0.174	0.469	.001	22	view →
CHOL	DFS	Tertile	All	0.722	0.095	.011	20	view →
ESCA	OS	Median	All	0.449	1.000	.011	20	view →
KICH	DFS	Quartile	All	0.585	0.936	.013	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CHMP4C–KIRC (DFS)

Open the KIRC breakdown →