CHMP4C

Across TCGA pan-cancer cohorts, CHMP4C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CHMP4C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHMP4C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP4C is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, LIHC, and UCEC are the cancer types where CHMP4C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP4C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.032	<.001	9	view →
LIHC	Male	All	+1.087	<.001	7	view →
UCEC	All	All	+2.143	<.001	6	view →
BLCA	All	All	+1.692	.004	6	view →
COAD	Male	All	+0.951	<.001	6	view →
BRCA	All	II,III,IV	+0.714	<.001	6	view →
CHOL	All	All	+2.904	<.001	5	view →
LUSC	Male	All	+0.793	<.001	5	view →
STAD	All	All	+1.373	.001	4	view →
PRAD	All	All	+0.737	<.001	2	view →
KICH	All	All	−0.734	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CHMP4C–LUAD

Open the LUAD breakdown →