CHMP4C

Across TCGA cell cohorts, CHMP4C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CHMP4C-associated GO terms across cancer lineages are Negative regulation of endodermal cell differentiation, Response to indole-3-methanol, and Cellular response to indole-3-methanol. Each is linked with CHMP4C in more than 10 cancer types. Because this analysis shows association rather than direction, both CHMP4C-to-partner and partner-to-CHMP4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endodermal cell differentiation grouped by CHMP4C-low versus CHMP4C-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4C→partner) and Y-score (partner→CHMP4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of endodermal cell differentiation →	-1.564	-2.821	<.001	.001	3	11
LUNG_SCLC	Response to indole-3-methanol →	+0.215	+2.559	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Cellular response to indole-3-methanol →	+0.192	+1.447	<.001	<.001	3	10
OESOPHAGUS	Nuclear membrane reassembly →	+0.120	+1.647	.002	.006	2	11
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.170	+2.113	.002	.001	3	10
OESOPHAGUS	Lysosomal membrane organization →	+0.130	+1.620	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

Negative regulation of endodermal cell differentiation by CHMP4C expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →