CHMP4B

Across TCGA patient cohorts, CHMP4B mutation is significantly associated with the RNA expression of many other genes, with 386 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP4B-associated genes across cancer lineages are RNA5SP367, MIR4507, and TRAJ21. Each is linked with CHMP4B in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP4B-to-partner and partner-to-CHMP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP367 grouped by CHMP4B-low versus CHMP4B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4B→partner) and Y-score (partner→CHMP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP367 →	+0.372	+5.010	<.001	.009	3	2
UCEC	MIR4507 →	+0.296	+3.098	<.001	.002	3	2
UCEC	TRAJ21 →	+0.596	+2.936	<.001	<.001	3	2
UCEC	RNU6-751P →	+0.144	+4.151	<.001	.006	3	2
UCEC	IGHVIII-22-2 →	+0.500	+3.229	.001	.001	3	2
CESC	MTND1P2 →	+0.098	+5.201	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 386 associations by consensus.

RNA5SP367 by CHMP4B expression — CESC

Explore this box plot interactively →