CHMP4B

Across TCGA pan-cancer cohorts, CHMP4B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CHMP4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHMP4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP4B is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where CHMP4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.707	<.001	11	view →
KIRC	Male	All	+0.378	<.001	10	view →
LIHC	Female	II,III,IV	+1.202	<.001	9	view →
LUAD	Female	III,IV	+0.614	<.001	8	view →
KIRP	All	All	+0.403	.001	7	view →
BRCA	All	III,IV	+0.833	<.001	6	view →
KICH	All	All	−0.551	<.001	6	view →
LUSC	All	All	+0.290	<.001	6	view →
CHOL	Male	All	+2.675	<.001	5	view →
STAD	Male	II,III,IV	+0.577	.001	5	view →
READ	Male	All	−0.426	.026	4	view →
ESCA	All	All	+1.046	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CHMP4B–HNSC

Open the HNSC breakdown →