CHMP4B

Across TCGA pan-cancer cohorts, CHMP4B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CHMP4B data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CHMP4B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHMP4B expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

UVM, LIHC, and PAAD are the cancer types where CHMP4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.459	0.793	.002	69	view →
LIHC	DFS	Median	All	0.466	0.612	<.001	64	view →
PAAD	DFS	Median	All	0.187	0.400	.001	40	view →
LAML	DFS	Tertile	All	0.305	0.549	.001	38	view →
KICH	DFS	Median	All	0.719	1.000	.006	33	view →
KIRP	DFS	Quartile	All	0.587	1.000	.003	31	view →
LGG	OS	Median	All	0.755	0.864	<.001	19	view →
CESC	DFS	Median	IV	0.094	0.473	.019	18	view →
ACC	DFS	Tertile	All	0.399	0.741	.003	14	view →
KIRC	DFS	Median	II,III,IV	0.610	0.349	.010	12	view →
UCEC	DFS	Median	All	0.550	0.730	.016	10	view →
THCA	OS	Tertile	II,III,IV	1.000	0.778	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CHMP4B–UVM (OS)

Open the UVM breakdown →