CHMP4B

Across TCGA patient cohorts, CHMP4B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP4B-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Caspase-7-cleavedD198. Each is linked with CHMP4B in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP4B-to-partner and partner-to-CHMP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CHMP4B-low versus CHMP4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4B→partner) and Y-score (partner→CHMP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.521	+3.000	.006	.036	3	1
UCEC	p62 Lck ligand →	+0.352	+3.321	.039	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+1.034	+3.019	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.458	-2.990	<.001	.036	2	1
UCEC	MSH2 →	-0.314	-3.321	.009	.010	1	1
UCEC	MSH6 →	-0.553	-3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by CHMP4B expression — UCEC

Explore this box plot interactively →