CHMP1B

Across TCGA patient cohorts, CHMP1B mutation is significantly associated with the RNA expression of many other genes, with 2,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP1B-associated genes across cancer lineages are RPS15AP3, SLC6A14P3, and OR8F1P. Each is linked with CHMP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP1B-to-partner and partner-to-CHMP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS15AP3 grouped by CHMP1B-low versus CHMP1B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP1B→partner) and Y-score (partner→CHMP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPS15AP3 →	+0.179	+5.273	<.001	.006	3	2
CESC	SLC6A14P3 →	+0.089	+4.757	<.001	.004	3	2
LIHC	OR8F1P →	+0.057	+5.878	<.001	.002	3	2
CESC	RN7SL543P →	+0.107	+3.760	.005	.007	3	2
LIHC	KRTAP21-1 →	+0.086	+5.758	<.001	.003	3	2
CESC	RNU6-1228P →	+0.184	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,894 associations by consensus.

RPS15AP3 by CHMP1B expression — LUSC

Explore this box plot interactively →