Across TCGA patient cohorts, CHML mutation is significantly associated with the RNA expression of many other genes, with 5,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHML-associated genes across cancer lineages are RNA5SP385, RNU5E-10P, and RNA5SP213. Each is linked with CHML in more than 2 cancer types. Because this analysis shows association rather than direction, both CHML-to-partner and partner-to-CHML results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHML→partner) and Y-score (partner→CHML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP385 →	+0.523	+4.225	<.001	.007	3	3
HNSC	RNU5E-10P →	+0.602	+3.830	<.001	.003	3	2
HNSC	RNA5SP213 →	+0.166	+4.547	<.001	.004	3	2
BLCA	RNA5SP41 →	+0.187	+4.314	.001	.009	3	2
BLCA	MTND3P1 →	+0.169	+4.376	<.001	.002	3	2
CESC	IGKV3D-31 →	+0.275	+5.812	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,079 associations by consensus.

Exploration

CHML survival (RNA) · tumor vs normal (RNA) · all CHML data types