CHIA

Across TCGA patient cohorts, CHIA protein abundance is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CHIA-associated genes across cancer lineages are FGFR1OP2, MAK, and MAPK14. Each is linked with CHIA in more than 1 cancer types. Because this analysis shows association rather than direction, both CHIA-to-partner and partner-to-CHIA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHIA versus FGFR1OP2 in BRCA, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIA→partner) and Y-score (partner→CHIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGFR1OP2 →	-0.506	-0.772	.002	.007	3	1
BRCA	MAK →	-1.091	-1.102	<.001	<.001	3	1
BRCA	MAPK14 →	-0.915	-1.002	<.001	<.001	3	1
BRCA	EYA4 →	-0.425	-1.087	.008	.003	3	1
BRCA	SWT1 →	-0.905	-1.025	.009	.001	3	1
BRCA	ESYT2 →	-0.656	-0.796	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

CHIA vs FGFR1OP2 — BRCA

Explore this scatter interactively →