CHIA

Across TCGA pan-cancer cohorts, CHIA RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated CHIA data layer compared with 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHIA RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHIA expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, KIRP, and LUSC are the cancer types where CHIA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.862	0.760	<.001	67	view →
KIRP	OS	Median	All	0.467	0.808	<.001	61	view →
LUSC	DFS	Quartile	II,III,IV	0.253	0.509	.002	52	view →
HNSC	DFS	Tertile	All	0.799	0.674	.002	44	view →
MESO	DFS	Tertile	All	0.099	0.487	<.001	36	view →
BLCA	OS	Median	All	0.674	0.560	.013	29	view →
PAAD	OS	Quartile	II,III,IV	0.695	0.351	.013	12	view →
THCA	DFS	Median	IV	0.474	0.849	.011	11	view →
ACC	OS	Quartile	III,IV	0.538	0.800	.009	11	view →
ESCA	OS	Median	II,III,IV	0.599	0.380	.020	10	view →
SKCM	DFS	Tertile	IV	0.040	0.620	.003	9	view →
LGG	OS	Quartile	All	0.942	0.850	.001	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

CHIA–LUAD (OS)

Open the LUAD breakdown →