CHIA

Across TCGA pan-cancer cohorts, CHIA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CHIA’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CHIA RNA is repressed in tumor relative to normal tissue. In most cancer types CHIA is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and STAD are the cancer types where CHIA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHIA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−3.129	<.001	9	view →
LUAD	Female	II,III,IV	−2.107	<.001	8	view →
STAD	All	All	−0.956	.027	4	view →
KIRC	Male	IV	−0.102	.008	2	view →
PRAD	All	All	−0.100	.044	2	view →
COAD	Female	All	+0.014	.040	2	view →
ESCA	All	All	−4.126	.021	1	view →
KIRP	Male	All	−0.164	.045	1	view →
HNSC	Male	All	−0.018	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CHIA–LUSC

Open the LUSC breakdown →