CHIA

Across TCGA cell cohorts, CHIA RNA expression is significantly associated with the go_rna of many other GO terms, with 262 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CHIA-associated GO terms across cancer lineages are Positive regulation of heat generation, Protein transport within lipid bilayer, and Regulation of DNA stability. Each is linked with CHIA in more than 2 cancer types. Because this analysis shows association rather than direction, both CHIA-to-partner and partner-to-CHIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of heat generation grouped by CHIA-low versus CHIA-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIA→partner) and Y-score (partner→CHIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of heat generation →	+0.934	+0.030	.008	.007	3	2
LUNG_SCLC	Protein transport within lipid bilayer →	+0.257	+0.481	<.001	.006	3	2
LUNG_SCLC	Regulation of DNA stability →	+0.102	+0.405	<.001	.002	3	2
SOFT_TISSUE	Determination of dorsal identity →	-1.065	-0.054	<.001	.009	3	2
LUNG_SCLC	Regulation of inositol phosphate biosynthetic process →	-1.089	-0.431	<.001	.001	3	2
LUNG_SCLC	Negative regulation of meiotic cell cycle phase transition →	+0.094	+0.522	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

Positive regulation of heat generation by CHIA expression — SOFT_TISSUE

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