CHIA

Across TCGA cell cohorts, CHIA mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CHIA-associated genes across cancer lineages are C20orf85, OR1L4, and OR4D6. Each is linked with CHIA in more than 1 cancer types. Because this analysis shows association rather than direction, both CHIA-to-partner and partner-to-CHIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by CHIA-low versus CHIA-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIA→partner) and Y-score (partner→CHIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR51L1 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR51G2 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	SSX7 →	+0.022	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

C20orf85 by CHIA expression — SOFT_TISSUE

Explore this box plot interactively →