CHI3L2

Across TCGA cell cohorts, CHI3L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,798 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CHI3L2-associated GO terms across cancer lineages are Maintenance of protein localization in organelle, Regulation of ATP biosynthetic process, and Regulation of proteolysis. Each is linked with CHI3L2 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHI3L2-to-partner and partner-to-CHI3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of protein localization in organelle grouped by CHI3L2-low versus CHI3L2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L2→partner) and Y-score (partner→CHI3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maintenance of protein localization in organelle →	+0.132	+1.284	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of ATP biosynthetic process →	+0.125	+0.581	<.001	.003	3	8
BONE	Regulation of proteolysis →	+0.150	+1.429	<.001	<.001	3	8
BONE	Glial cell migration →	+0.144	+1.096	<.001	.001	3	7
BONE	Pyrimidine-containing compound transmembrane transport →	-0.144	-1.192	<.001	<.001	3	7
LARGE_INTESTINE	Positive regulation of intracellular transport →	+0.048	+0.194	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,798 associations by consensus.

Maintenance of protein localization in organelle by CHI3L2 expression — BONE

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