CHI3L2

Across TCGA cell cohorts, CHI3L2 mutation is significantly associated with the RNA expression of many other genes, with 129 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHI3L2-associated genes across cancer lineages are CA2, ATP5F1E, and CLEC18C. Each is linked with CHI3L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHI3L2-to-partner and partner-to-CHI3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA2 grouped by CHI3L2-low versus CHI3L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L2→partner) and Y-score (partner→CHI3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CA2 →	+1.986	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ATP5F1E →	-0.846	-3.169	<.001	.009	3	1
LARGE_INTESTINE	CLEC18C →	+0.117	+2.748	.005	.004	3	1
LARGE_INTESTINE	DMXL1 →	+0.582	+3.212	.004	.006	3	1
LARGE_INTESTINE	RNLS →	-1.505	-3.169	<.001	.009	3	1
LARGE_INTESTINE	IFNLR1 →	+0.701	+3.067	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 129 associations by consensus.

CA2 by CHI3L2 expression — LARGE_INTESTINE

Explore this box plot interactively →