CHDH

Across TCGA patient cohorts, CHDH mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHDH-associated genes across cancer lineages are ASNS, Cyclin-B1, and ACC1. Each is linked with CHDH in more than 1 cancer types. Because this analysis shows association rather than direction, both CHDH-to-partner and partner-to-CHDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CHDH-low versus CHDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHDH→partner) and Y-score (partner→CHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.630	+3.584	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.745	+2.459	.005	.020	3	2
UCEC	ACC1 →	+0.424	+2.459	.015	.020	3	1
UCEC	JNK2 →	+0.251	+3.026	.008	.018	3	1
UCEC	Ku80 →	+0.251	+3.009	.028	.019	3	1
UCEC	MEK1 →	+0.395	+2.999	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by CHDH expression — UCEC

Explore this box plot interactively →