CHDH

Across TCGA pan-cancer cohorts, CHDH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHDH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CHDH RNA is repressed in tumor relative to normal tissue. In most cancer types CHDH is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where CHDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.531	<.001	10	view →
HNSC	All	All	−0.769	<.001	9	view →
KIRC	Male	All	−1.094	<.001	8	view →
STAD	Male	II,III,IV	+2.110	<.001	7	view →
BLCA	All	All	+0.711	.002	7	view →
COAD	Male	All	+0.892	<.001	6	view →
LIHC	All	All	+0.448	.002	6	view →
KIRP	All	III,IV	−1.208	.008	5	view →
LUSC	Male	II,III,IV	−1.106	<.001	5	view →
THCA	All	All	−0.386	<.001	4	view →
PRAD	All	All	+1.256	<.001	2	view →
READ	Female	All	+1.002	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHDH–KICH

Open the KICH breakdown →