CHDH

Across TCGA pan-cancer cohorts, CHDH RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CHDH data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CHDH RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHDH expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, KIRC, and HNSC are the cancer types where CHDH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.802	0.576	<.001	163	view →
KIRC	OS	Median	All	0.730	0.534	<.001	146	view →
HNSC	DFS	Median	IV	0.738	0.542	<.001	71	view →
COAD	OS	Tertile	III,IV	0.868	0.647	<.001	66	view →
SKCM	DFS	Median	All	0.695	0.541	<.001	57	view →
BRCA	OS	Tertile	III,IV	0.975	0.828	<.001	35	view →
STAD	DFS	Median	III,IV	0.580	0.365	.005	31	view →
OV	DFS	Tertile	All	0.602	0.471	.004	20	view →
READ	OS	Quartile	II,III,IV	1.000	0.847	.009	20	view →
ACC	OS	Quartile	All	1.000	0.764	.007	18	view →
LUSC	OS	Median	III,IV	0.205	0.765	.006	17	view →
UCS	OS	Median	III,IV	0.528	0.207	.019	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CHDH–KIRP (OS)

Open the KIRP breakdown →