CHDH

Across TCGA cell cohorts, CHDH mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHDH-associated genes across cancer lineages are Mirin, PLK_6522, and Luminespib. Each is linked with CHDH in more than 1 cancer types. Because this analysis shows association rather than direction, both CHDH-to-partner and partner-to-CHDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by CHDH-low versus CHDH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHDH→partner) and Y-score (partner→CHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.462	+2.646	.014	.047	3	1
LARGE_INTESTINE	PLK_6522 →	+0.713	+2.649	.030	.046	3	1
LARGE_INTESTINE	Luminespib →	+0.706	+2.646	.020	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.511	+2.649	.043	.046	3	1
LARGE_INTESTINE	50869 →	+0.453	+2.649	.032	.046	3	1
LARGE_INTESTINE	630600 →	+0.743	+2.649	.016	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Mirin by CHDH expression — LARGE_INTESTINE

Explore this box plot interactively →