CHCHD2

Across TCGA patient cohorts, CHCHD2 mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CHCHD2-associated genes across cancer lineages are HMGXB4, MRPS15, and DEPDC1. Each is linked with CHCHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD2-to-partner and partner-to-CHCHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by CHCHD2-low versus CHCHD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD2→partner) and Y-score (partner→CHCHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGXB4 →	+0.570	+3.369	.009	.004	3	2
SKCM	MRPS15 →	+0.416	+2.826	.001	.001	3	2
SKCM	DEPDC1 →	+0.830	+3.331	.004	.005	3	2
SKCM	RN7SKP60 →	+0.063	+3.353	<.001	.003	3	2
COAD	ZYXP1 →	+0.911	+7.741	<.001	.009	3	2
SKCM	RNU6ATAC6P →	+0.152	+3.084	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

HMGXB4 by CHCHD2 expression — SKCM

Explore this box plot interactively →