CHCHD2

Across TCGA pan-cancer cohorts, CHCHD2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CHCHD2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHCHD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHCHD2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where CHCHD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.173	<.001	12	view →
KIRC	All	III,IV	+0.284	<.001	12	view →
COAD	Female	II,III,IV	+0.965	<.001	11	view →
KIRP	All	II,III,IV	+0.600	<.001	11	view →
LIHC	Female	All	+0.986	<.001	9	view →
LUAD	Female	All	+0.667	<.001	8	view →
BLCA	All	All	+0.644	.001	8	view →
BRCA	All	III,IV	+0.669	<.001	6	view →
STAD	All	II,III,IV	+0.521	<.001	6	view →
CHOL	All	All	+1.311	<.001	5	view →
LUSC	Male	All	+0.781	<.001	5	view →
KICH	All	All	−0.445	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CHCHD2–HNSC

Open the HNSC breakdown →