CHCHD1

Across TCGA patient cohorts, CHCHD1 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible CHCHD1-associated genes across cancer lineages are LINC02564, RNU6-1297P, and RNU6-1236P. Each is linked with CHCHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD1-to-partner and partner-to-CHCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02564 grouped by CHCHD1-low versus CHCHD1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD1→partner) and Y-score (partner→CHCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC02564 →	+0.050	+5.912	<.001	.002	3	2
UCEC	RNU6-1297P →	+0.671	+4.578	.003	.004	3	2
SKCM	RNU6-1236P →	+0.921	+4.381	<.001	.006	3	2
BLCA	CHCHD2P1 →	+0.203	+3.719	<.001	.008	3	2
BLCA	RNA5SP468 →	+0.453	+5.057	<.001	<.001	3	2
BLCA	RNU6-909P →	+1.528	+3.883	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

LINC02564 by CHCHD1 expression — HNSC

Explore this box plot interactively →