CHCHD1

Across TCGA pan-cancer cohorts, CHCHD1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHCHD1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CHCHD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHCHD1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

LIHC, KICH, and LUAD are the cancer types where CHCHD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.061	<.001	9	view →
KICH	Female	All	−0.986	<.001	8	view →
LUAD	Male	II,III,IV	+0.669	<.001	7	view →
STAD	All	II,III,IV	+0.584	<.001	7	view →
UCEC	All	III,IV	+0.881	<.001	6	view →
BRCA	All	III,IV	+0.783	<.001	6	view →
BLCA	All	All	+0.546	.001	6	view →
CHOL	Male	All	+1.361	<.001	5	view →
COAD	All	II,III,IV	+0.296	.005	4	view →
LUSC	All	All	+0.278	.004	4	view →
ESCA	All	All	+0.557	.031	1	view →
COAD	Female	IV	−0.489	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHCHD1–LIHC

Open the LIHC breakdown →