CHAF1B

Across TCGA patient cohorts, CHAF1B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAF1B-associated genes across cancer lineages are IGFBP2, JNK2, and Ku80. Each is linked with CHAF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAF1B-to-partner and partner-to-CHAF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by CHAF1B-low versus CHAF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAF1B→partner) and Y-score (partner→CHAF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.945	-2.807	<.001	.003	3	1
UCEC	JNK2 →	+0.265	+2.331	.002	.019	3	1
UCEC	Ku80 →	+0.263	+3.331	.010	.005	3	1
UCEC	MEK1 →	+0.331	+2.321	.038	.034	3	1
UCEC	p62 Lck ligand →	+0.303	+2.807	.033	.003	3	1
SKCM	p27 →	-0.306	-3.169	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

IGFBP2 by CHAF1B expression — UCEC

Explore this box plot interactively →