CHAF1B

Across TCGA pan-cancer cohorts, CHAF1B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CHAF1B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CHAF1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHAF1B is over-expressed in tumor.

BLCA, COAD, and HNSC are the cancer types where CHAF1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHAF1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.031	<.001	12	view →
COAD	All	III,IV	+1.341	<.001	11	view →
HNSC	Male	III,IV	+1.111	<.001	10	view →
THCA	Male	III,IV	+0.899	<.001	10	view →
LUAD	Male	III,IV	+1.818	<.001	9	view →
LIHC	Female	II,III,IV	+1.622	<.001	9	view →
STAD	Male	II,III,IV	+1.347	<.001	9	view →
LUSC	Female	All	+2.627	<.001	8	view →
KIRP	All	II,III,IV	+0.901	<.001	8	view →
UCEC	All	II,III,IV	+1.364	<.001	6	view →
BRCA	All	II,III,IV	+1.179	<.001	6	view →
CHOL	Male	All	+2.771	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CHAF1B–BLCA

Open the BLCA breakdown →