CHAF1B

Across TCGA pan-cancer cohorts, CHAF1B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CHAF1B data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHAF1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHAF1B expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

ACC, KIRP, and MESO are the cancer types where CHAF1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.381	0.775	<.001	139	view →
KIRP	DFS	Median	All	0.854	0.961	<.001	136	view →
MESO	OS	Median	All	0.371	0.700	<.001	135	view →
LIHC	DFS	Median	All	0.428	0.651	<.001	85	view →
KICH	DFS	Tertile	All	0.591	1.000	<.001	67	view →
READ	OS	Median	All	0.925	0.457	<.001	62	view →
KIRC	DFS	Tertile	IV	0.129	0.461	.001	60	view →
LGG	DFS	Median	All	0.639	0.836	<.001	54	view →
LUAD	OS	Tertile	All	0.587	0.762	<.001	41	view →
THCA	DFS	Median	III,IV	0.536	0.855	.002	41	view →
SARC	OS	Quartile	All	0.279	0.760	<.001	31	view →
UVM	OS	Median	II,III,IV	0.738	0.944	.003	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CHAF1B–ACC (DFS)

Open the ACC breakdown →