CHAF1A

Across TCGA cell cohorts, CHAF1A mutation is significantly associated with the RNA expression of many other genes, with 735 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHAF1A-associated genes across cancer lineages are MMP26, NT5DC3, and PWWP3A. Each is linked with CHAF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAF1A-to-partner and partner-to-CHAF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by CHAF1A-low versus CHAF1A-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAF1A→partner) and Y-score (partner→CHAF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	2
LARGE_INTESTINE	NT5DC3 →	+0.894	+2.502	<.001	.005	3	2
LARGE_INTESTINE	PWWP3A →	+0.657	+2.502	.002	.005	3	2
LARGE_INTESTINE	KCNRG →	+0.404	+3.628	.007	<.001	3	2
BLOOD_Leukemia	PRAC1 →	+0.562	+3.884	.005	.003	3	1
BLOOD_Leukemia	GOT1L1 →	+0.040	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 735 associations by consensus.

MMP26 by CHAF1A expression — BLOOD_Myeloma

Explore this box plot interactively →