CHAF1A

Across TCGA pan-cancer cohorts, CHAF1A RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated CHAF1A data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CHAF1A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHAF1A expression acts as an unfavorable survival marker, although some lineages such as CESC and HNSC show a favorable association.

MESO, ACC, and CESC are the cancer types where CHAF1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.376	0.708	<.001	150	view →
ACC	OS	Median	All	0.352	0.852	<.001	142	view →
CESC	DFS	Tertile	All	0.866	0.677	<.001	68	view →
KICH	DFS	Quartile	III,IV	0.086	1.000	.007	63	view →
LGG	OS	Median	All	0.741	0.883	<.001	52	view →
HNSC	OS	Quartile	All	0.807	0.590	<.001	52	view →
LIHC	OS	Tertile	All	0.685	0.849	<.001	46	view →
SKCM	OS	Tertile	All	0.281	0.591	.001	42	view →
KIRC	DFS	Tertile	III,IV	0.614	0.264	.002	40	view →
STAD	OS	Tertile	III,IV	0.747	0.549	.005	39	view →
LUAD	DFS	Median	All	0.740	0.837	<.001	38	view →
UVM	DFS	Tertile	II,III,IV	0.326	0.684	.003	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

CHAF1A–MESO (OS)

Open the MESO breakdown →