CH25H

Across TCGA patient cohorts, CH25H mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CH25H-associated genes across cancer lineages are EGFR, MSH2, and Myosin-IIa. Each is linked with CH25H in more than 1 cancer types. Because this analysis shows association rather than direction, both CH25H-to-partner and partner-to-CH25H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by CH25H-low versus CH25H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CH25H→partner) and Y-score (partner→CH25H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.251	-3.000	.001	.036	3	1
UCEC	MSH2 →	-0.273	-2.990	.018	.036	3	1
UCEC	Myosin-IIa →	+0.249	+2.329	.007	.020	3	1
UCEC	Notch1 →	+0.258	+3.179	<.001	.010	3	1
UCEC	p21 →	+0.219	+3.459	.023	.005	3	1
UCEC	p90 RSK_pT359_S363 →	-0.238	-2.321	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR by CH25H expression — UCEC

Explore this box plot interactively →