CH25H

Across TCGA pan-cancer cohorts, CH25H RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CH25H’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CH25H RNA is repressed in tumor relative to normal tissue. In most cancer types CH25H is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and LUSC are the cancer types where CH25H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CH25H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.761	<.001	11	view →
BLCA	All	III,IV	−2.011	<.001	9	view →
LUSC	Male	II,III,IV	−2.713	<.001	8	view →
HNSC	Male	IV	−2.033	<.001	8	view →
UCEC	All	All	−1.182	<.001	8	view →
THCA	All	III,IV	+1.776	<.001	7	view →
KIRP	All	All	−1.209	<.001	7	view →
BRCA	All	II,III,IV	−0.935	<.001	6	view →
KIRC	Male	II,III,IV	−0.910	<.001	4	view →
LUAD	All	All	−0.629	.015	3	view →
PRAD	All	All	−0.752	.001	2	view →
STAD	All	All	−0.799	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CH25H–KICH

Open the KICH breakdown →