CH25H

Across TCGA pan-cancer cohorts, CH25H RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CH25H data layer compared with 2 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CH25H RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CH25H expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

OV, HNSC, and UVM are the cancer types where CH25H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.795	0.900	<.001	58	view →
HNSC	DFS	Median	III,IV	0.461	0.232	<.001	45	view →
UVM	DFS	Tertile	II,III,IV	0.406	0.730	.001	44	view →
LUAD	OS	Median	All	0.753	0.619	<.001	44	view →
SKCM	OS	Quartile	II,III,IV	0.451	0.200	<.001	34	view →
CESC	OS	Quartile	All	0.954	0.818	<.001	32	view →
KIRC	DFS	Quartile	All	0.697	0.850	.008	28	view →
CHOL	DFS	Median	All	0.641	0.163	.001	18	view →
ACC	OS	Quartile	III,IV	0.159	0.686	.035	16	view →
MESO	OS	Tertile	III,IV	0.267	0.731	.006	15	view →
LGG	OS	Quartile	All	0.950	0.830	.005	14	view →
LUSC	DFS	Median	III,IV	0.642	0.437	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CH25H–OV (OS)

Open the OV breakdown →