CGAS

Across TCGA patient cohorts, CGAS mutation is significantly associated with the RNA expression of many other genes, with 914 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGAS-associated genes across cancer lineages are RNU6-694P, XIRP1, and GLRX2. Each is linked with CGAS in more than 2 cancer types. Because this analysis shows association rather than direction, both CGAS-to-partner and partner-to-CGAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by CGAS-low versus CGAS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGAS→partner) and Y-score (partner→CGAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-694P →	+0.254	+4.308	.003	.009	3	3
UCEC	XIRP1 →	+0.206	+3.317	.002	.007	3	2
UCEC	GLRX2 →	+0.582	+3.595	.007	.001	3	2
BLCA	OR6K2 →	+0.031	+4.433	<.001	.007	3	2
UCEC	SFPQP1 →	+0.057	+2.518	<.001	.003	3	2
READ	CYCSP22 →	+0.151	+4.421	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

RNU6-694P by CGAS expression — COAD

Explore this box plot interactively →