CGAS

Across TCGA pan-cancer cohorts, CGAS RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CGAS data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CGAS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CGAS expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

UVM, MESO, and LGG are the cancer types where CGAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.265	0.748	<.001	94	view →
MESO	OS	Median	All	0.278	0.506	<.001	74	view →
LGG	DFS	Median	All	0.640	0.835	<.001	54	view →
SKCM	OS	Median	II,III,IV	0.414	0.201	<.001	38	view →
LIHC	OS	Tertile	III,IV	0.256	0.742	<.001	34	view →
COAD	DFS	Tertile	IV	0.323	0.613	.011	30	view →
KIRC	DFS	Tertile	II,III,IV	0.595	0.755	.008	25	view →
SARC	OS	Tertile	All	0.436	0.776	.006	14	view →
HNSC	OS	Median	III,IV	0.428	0.676	.007	13	view →
LUSC	DFS	Tertile	All	0.723	0.810	.010	13	view →
ESCA	DFS	Tertile	IV	0.242	0.692	.024	12	view →
LAML	DFS	Tertile	All	0.260	0.560	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CGAS–UVM (DFS)

Open the UVM breakdown →