CFTR-AS1

Across TCGA patient cohorts, CFTR-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,725 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CFTR-AS1-associated proteins across cancer lineages are RALGAPB, REPS2, and RGN. Each is linked with CFTR-AS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CFTR-AS1-to-partner and partner-to-CFTR-AS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CFTR-AS1 versus RALGAPB in PDAC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CFTR-AS1→partner) and Y-score (partner→CFTR-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RALGAPB →	+0.160	+1.362	.005	<.001	3	3
LSCC	REPS2 →	+0.299	+0.696	<.001	<.001	3	3
LSCC	RGN →	+0.567	+0.723	<.001	<.001	3	3
PDAC	SF3B1_T244 →	+0.436	+1.292	<.001	<.001	3	3
LUAD	SLC44A3_S639 →	+0.738	+0.864	.002	.003	3	3
LUAD	SORBS2 →	+0.520	+1.055	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,725 associations by consensus.

CFTR-AS1 vs RALGAPB — PDAC

Explore this scatter interactively →