CFTR-AS1

Across TCGA pan-cancer cohorts, CFTR-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated CFTR-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CFTR-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CFTR-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

BLCA, KIRC, and ESCA are the cancer types where CFTR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.248	0.720	.026	45	view →
KIRC	DFS	Tertile	IV	0.152	0.625	.003	36	view →
ESCA	OS	Tertile	All	0.201	0.951	<.001	36	view →
LAML	DFS	Tertile	All	0.082	0.582	.004	36	view →
STAD	OS	Quartile	III,IV	0.197	0.565	.006	18	view →
LUAD	DFS	Tertile	All	0.688	0.311	.028	18	view →
LGG	DFS	Tertile	All	0.379	0.739	.038	9	view →
LIHC	OS	Tertile	All	0.177	0.783	.003	9	view →
HNSC	DFS	Tertile	All	0.084	0.660	<.001	9	view →
COAD	OS	Median	IV	0.823	0.468	.017	6	view →
READ	OS	Tertile	III,IV	0.895	0.323	.006	6	view →
PAAD	DFS	Tertile	III,IV	0.357	0.908	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

CFTR-AS1–BLCA (OS)

Open the BLCA breakdown →