CFHR1

Across TCGA patient cohorts, CFHR1 mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR1-associated genes across cancer lineages are MIR193B, MTCYBP17, and LINC01861. Each is linked with CFHR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR1-to-partner and partner-to-CFHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR193B grouped by CFHR1-low versus CFHR1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR1→partner) and Y-score (partner→CFHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR193B →	+0.560	+3.642	<.001	.009	3	2
HNSC	MTCYBP17 →	+0.042	+5.221	<.001	.003	3	2
HNSC	LINC01861 →	+0.061	+5.339	<.001	.003	3	2
HNSC	LINC02143 →	+0.065	+5.608	<.001	.002	3	2
LUAD	DEFA11P →	+0.760	+4.263	<.001	.007	3	2
HNSC	RNU6-552P →	+0.243	+5.221	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

MIR193B by CFHR1 expression — BLCA

Explore this box plot interactively →