CFHR1

Across TCGA pan-cancer cohorts, CFHR1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CFHR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CFHR1 RNA is repressed in tumor relative to normal tissue. In most cancer types CFHR1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and CHOL are the cancer types where CFHR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CFHR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.727	<.001	12	view →
BRCA	Female	All	−0.101	.002	6	view →
CHOL	Female	All	−8.510	<.001	5	view →
KICH	All	All	−0.530	.003	4	view →
KIRP	All	All	−0.402	.001	4	view →
COAD	Female	IV	−0.055	.008	3	view →
THCA	Female	All	−0.043	.034	2	view →
PRAD	All	All	−0.014	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CFHR1–KIRC

Open the KIRC breakdown →