cilia and flagella associated protein 54Genealiases: C12orf55 · C12orf63 · CILD54 · SPGF98
Q-omics provides the consensus-scored CFAP54 profile across patient tissues and cancer cell-line models. CFAP54 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, CFAP54 is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, CFAP54 RNA expression shows 18,308 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, COAD, and UVM as cancer lineages where CFAP54 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CFAP54 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CFAP54 survival associations across molecular data types. CFAP54 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CFAP54 RNA expression–survival associations across cancer types. High CFAP54 expression shows unfavorable associations in KIRC, LGG, BLCA and ACC, but favorable associations in SKCM and BRCA. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for CFAP54 RNA expression.
This table summarizes CFAP54 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for CFAP54. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CFAP54 shows lower tumor expression in COAD, THCA, KIRC, LUSC and KICH and higher tumor expression in CHOL. The COAD box plot shows higher CFAP54 RNA expression in normal versus tumor tissue (log2 FC = −0.163, t-test p < 0.001).
This table shows molecular features associated with CFAP54 in patient tissues and cancer cell lines. In patient samples, CFAP54 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, CFAP54 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BREAST.
