CFAP46

Across TCGA patient cohorts, CFAP46 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP46-associated genes across cancer lineages are ATM, Rad50, and c-Jun_pS73. Each is linked with CFAP46 in more than 3 cancer types. Because this analysis shows association rather than direction, both CFAP46-to-partner and partner-to-CFAP46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CFAP46-low versus CFAP46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP46→partner) and Y-score (partner→CFAP46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-1.847	<.001	<.001	3	4
COAD	Rad50 →	-0.325	-3.087	<.001	<.001	3	3
CESC	c-Jun_pS73 →	-0.324	-3.321	.007	.009	3	3
COAD	FASN →	+0.252	+1.160	.030	.033	3	3
COAD	GSK-3_pS9 →	-0.275	-1.584	.018	.032	3	3
UCEC	4E-BP1 →	+0.393	+2.039	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

ATM by CFAP46 expression — UCEC

Explore this box plot interactively →