CFAP46

Across TCGA pan-cancer cohorts, CFAP46 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CFAP46’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CFAP46 RNA is repressed in tumor relative to normal tissue. In most cancer types CFAP46 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where CFAP46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CFAP46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.621	<.001	11	view →
KICH	Male	All	−0.931	<.001	10	view →
KIRC	Male	II,III,IV	−0.522	<.001	10	view →
LUSC	Male	II,III,IV	−1.113	<.001	8	view →
LUAD	All	II,III,IV	−0.704	<.001	8	view →
HNSC	Male	II,III,IV	−0.269	<.001	7	view →
COAD	All	II,III,IV	+0.113	.024	3	view →
CHOL	All	All	+0.731	<.001	2	view →
KIRP	Male	All	−0.329	.027	2	view →
BRCA	All	All	+0.149	.021	2	view →
PRAD	All	All	−0.104	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CFAP46–THCA

Open the THCA breakdown →