CFAP46

Across TCGA pan-cancer cohorts, CFAP46 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CFAP46 data layer compared with 7 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CFAP46 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CFAP46 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRP show a favorable association.

BRCA, KIRP, and ACC are the cancer types where CFAP46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.934	0.720	<.001	92	view →
KIRP	DFS	Median	II,III,IV	1.000	0.222	<.001	71	view →
ACC	DFS	Median	All	0.413	0.745	<.001	55	view →
UVM	DFS	Median	All	0.765	0.470	.003	49	view →
LGG	DFS	Tertile	All	0.640	0.791	<.001	40	view →
CESC	OS	Tertile	IV	0.698	0.086	.003	36	view →
SKCM	OS	Tertile	All	0.841	0.908	.003	20	view →
PAAD	OS	Median	All	0.744	0.521	.005	18	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →
UCEC	OS	Median	All	0.950	0.902	.020	12	view →
UCS	OS	Tertile	All	0.547	0.829	.006	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CFAP46–BRCA (OS)

Open the BRCA breakdown →