CES4A

Across TCGA patient cohorts, CES4A mutation is significantly associated with the RNA expression of many other genes, with 1,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CES4A-associated genes across cancer lineages are ARRDC3-AS1, UBE2DNL, and RN7SL82P. Each is linked with CES4A in more than 1 cancer types. Because this analysis shows association rather than direction, both CES4A-to-partner and partner-to-CES4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARRDC3-AS1 grouped by CES4A-low versus CES4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES4A→partner) and Y-score (partner→CES4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARRDC3-AS1 →	+0.239	+2.254	.005	.005	3	2
LUSC	UBE2DNL →	+0.100	+4.984	.006	.009	3	2
LUSC	RN7SL82P →	+0.246	+7.593	<.001	<.001	3	2
UCEC	CYP2J2 →	-1.107	-3.775	<.001	<.001	3	2
UCEC	ADAMTS17 →	-0.605	-3.636	.001	.001	3	2
UCEC	RNA5SP492 →	+0.243	+2.302	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,768 associations by consensus.

ARRDC3-AS1 by CES4A expression — UCEC

Explore this box plot interactively →