CERS4

Across TCGA patient cohorts, CERS4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS4-associated genes across cancer lineages are A-Raf_pS299, JNK2, and mTOR_pS2448. Each is linked with CERS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS4-to-partner and partner-to-CERS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CERS4-low versus CERS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS4→partner) and Y-score (partner→CERS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.149	-2.584	.007	.011	3	1
UCEC	JNK2 →	+0.283	+2.584	.002	.011	3	1
UCEC	mTOR_pS2448 →	-0.182	-3.156	.008	.018	3	1
UCEC	N-Cadherin →	+0.271	+2.999	.006	.035	3	1
UCEC	Notch1 →	+0.177	+3.331	.007	.005	3	1
UCEC	p62 Lck ligand →	+0.530	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A-Raf_pS299 by CERS4 expression — UCEC

Explore this box plot interactively →