CERS4

Across TCGA pan-cancer cohorts, CERS4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CERS4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CERS4 RNA is repressed in tumor relative to normal tissue. In most cancer types CERS4 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, KIRC, and KICH are the cancer types where CERS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CERS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.273	<.001	8	view →
KIRC	All	All	+0.291	.005	7	view →
KICH	Male	All	+1.328	<.001	6	view →
BLCA	All	All	−1.316	.002	6	view →
BRCA	All	III,IV	+1.205	<.001	6	view →
COAD	Male	All	−0.935	.001	6	view →
LIHC	All	All	+0.365	.015	3	view →
UCEC	All	II,III,IV	+1.003	.017	2	view →
PRAD	All	All	+0.865	<.001	2	view →
THCA	All	IV	−0.739	.043	1	view →
LUSC	All	All	−0.365	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CERS4–LUAD

Open the LUAD breakdown →