CERS4

Across TCGA pan-cancer cohorts, CERS4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CERS4 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CERS4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CERS4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, CESC, and LUAD are the cancer types where CERS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.742	0.560	<.001	99	view →
CESC	DFS	Quartile	All	0.700	0.413	<.001	92	view →
LUAD	OS	Median	All	0.426	0.255	<.001	87	view →
KIRP	OS	Tertile	II,III,IV	0.823	0.162	<.001	59	view →
PAAD	OS	Tertile	All	0.603	0.267	<.001	54	view →
KIRC	DFS	Tertile	All	0.866	0.690	.006	52	view →
STAD	DFS	Quartile	All	0.210	0.471	.013	28	view →
LAML	DFS	Tertile	All	0.535	0.267	.009	28	view →
BRCA	DFS	Quartile	III,IV	0.943	0.812	.009	18	view →
ESCA	OS	Quartile	All	1.000	0.343	.009	18	view →
THCA	OS	Tertile	III,IV	1.000	0.941	.021	15	view →
MESO	OS	Quartile	All	0.680	0.123	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CERS4–HNSC (OS)

Open the HNSC breakdown →