CERS4

Across TCGA cell cohorts, CERS4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CERS4-associated genes across cancer lineages are CLPS, OR10G4, and OR10W1. Each is linked with CERS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS4-to-partner and partner-to-CERS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPS grouped by CERS4-low versus CERS4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS4→partner) and Y-score (partner→CERS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLPS →	+0.218	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.016	+5.228	<.001	.005	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.562	<.001	.002	3	1
LARGE_INTESTINE	HMX3 →	+0.711	+3.794	<.001	.001	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+3.614	<.001	.006	3	1
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CLPS by CERS4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →