CEP250

Across TCGA cell cohorts, CEP250 mutation is significantly associated with the RNA expression of many other genes, with 448 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP250-associated genes across cancer lineages are PRAMEF9, ZCRB1, and PTF1A. Each is linked with CEP250 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP250-to-partner and partner-to-CEP250 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF9 grouped by CEP250-low versus CEP250-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP250→partner) and Y-score (partner→CEP250) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.005	+3.228	.002	.003	3	3
BLOOD_Leukemia	ZCRB1 →	+0.467	+3.259	.006	.006	3	3
URINARY_TRACT	PTF1A →	+0.070	+4.087	<.001	.009	3	2
URINARY_TRACT	CA5A →	+0.015	+4.087	<.001	.009	3	2
URINARY_TRACT	HORMAD2 →	+0.006	+4.217	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	OR51I1 →	+0.060	+3.917	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 448 associations by consensus.

PRAMEF9 by CEP250 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →